Investigator Sponsored Trial (IST)

Agenus will consider IST’s utilizing botensilimab +/- balstilimab or other agents external to our pipeline. Other agents in our pipeline are not currently open to IST proposals except on a case-by-case basis. Particular consideration will be given to IST’s designed to:

  • Improve on standard of care in early lines of therapy, i.e. neoadjuvant, adjuvant, or 1L therapy.
  • Overcome primary and secondary resistance to immunotherapy including liver and/or brain metastases.
  • Improve management of immune related adverse events, including prophylaxis strategies for immune mediated diarrhea/colitis.

Additional consideration will be given to studies that have:

  • A strong translational component that may help elucidate mechanism of action and contribute to predictive models/signatures.
  • Adaptive or innovative trial designs that more efficiently evaluate biomarker selected populations with varied mechanisms of resistance.
  • A strong rationale for exploring monotherapy and/or combination(s) in a population considered unlikely to respond to immunotherapy.
Important Notes
  • This IST portal is only to be used to request support for an Investigator Sponsored Trial (IST).
  • Requests must be submitted at least 12 weeks prior to the study start date, to ensure adequate time for your request to be reviewed and processed.
  • Agenus may support an IST with funding and/or drug supply or materials (including Agenus information, placebo, or other medicinal products necessary for the research).
  • We encourage investigators to review our frequently asked questions (FAQ). Please contact us should you need additional information.
  • Successfully completed submissions will receive an automated confirmation email. Please save often in case the application times out due to inactivity.
  • IST approvals are not contingent in any way on the use of, purchase of, prescribing of, recommendation for or other support for any current or future Agenus product. All IST funding is conducted in accordance with the recommendations and requirements of the Food and Drug Administration (FDA) guidelines, applicable laws as well as internal company policies and guidelines.

Getting Started

If this is your first time applying for an IST, please register by clicking on the "Register" button to the right. Otherwise, login to the IST Portal using your email and password.

Login

Please log in to the IST Portal by entering your email and password in the fields below:




If you don't have a username and password, you must first register to access the IST Portal. Click the Register button below and follow the instructions on the registration screen.

Register