Investigator Sponsored Trial (IST)

Agenus is committed to providing support for Investigator Sponsored Trials (IST). 

The evaluation criteria include:

  • Scientific merit
  • Business strategy alignment
  • Investigator qualifications
  • Agenus resources

Agenus IST Committee will share further information following review of your concept proposal.

Therapeutic Areas Supported
  • Gynecologic cancer
  • Melanoma
  • Non-Melanoma skin cancers
  • Sarcomas
  • MSS tumors (i.e. endometrial and colorectal)
  • Lung
  • Renal Cell Carcinoma
  • Hepatocellular Carcinoma
  • Bladder Cancer
  • Metastatic adrenocortical carcinoma
  • Cholangiocarcinoma
  • Glioblastoma - Vaccine
  • Pediatric Gliomas – Vaccine
Important Notes
  • This IST portal is only to be used to request support for an Investigator Sponsored Trial (IST).
  • Requests for educational grants, CME, etc. should be done through our Agenus Grant Request Portal at
  • Requests must be submitted at least 12 weeks prior to the study start date, to ensure adequate time for your request to be reviewed and processed.
  • Agenus may support an IST with funding and/or drug supply or materials (including Agenus information, placebo, or other medicinal products necessary for the research)
  • We encourage investigators to review our frequently asked questions (FAQ).  Please contact us should you need additional information.
  • Successfully completed submissions will receive an automated confirmation email. Please save often in case the application times out due to inactivity.
  • IST approvals are not contingent in any way on the use, purchase, prescribing, providing favorable recommendation for or otherwise supporting any current or future Agenus product. All IST funding is conducted in accordance with the recommendations and requirements of the Food and Drug Administration (FDA) guidelines, applicable laws as well as internal company policies and guidelines.

Getting Started

If this is your first time applying for an IST, please register by clicking on the "Register" button to the right. Otherwise, login to the IST Portal using your email and password.


Please log in to the IST Portal by entering your email and password in the fields below:

If you don't have a username and password, you must first register to access the IST Portal. Click the Register button below and follow the instructions on the registration screen.